Clarksdale is less than 2 hours from Memphis, so you should have time to expand your trip and cover quite a bit of the cradle of the Blues. The two main highways are US 61 & US49. These split at Clarksdale. Maybe concider doing a circular tour going as far south as Yazoo City, to encompass many juke joints and historic sites. Copy and paste the two addresses below for more info. Have a great time!
I would suggest you take Hwy 61 from Memphis.
Are you staying in Clarksdale? When are you coming?
In Clarksdale I would suggest Ground Zero Blues Club (live music usually on Thurs, Fri and Sat nights), The Delta Blues Museum (1/2 block from GZ0) and The Cats Head Store (sells blues related items as well as cd's by local artists).
I would suggest that you consider visiting The BB King Museum in Indianola Ms. Indianola is about an hour and a half drive from Clarksdale and is worth the effort. You would drive south on Hwy 61, Exit onto Hwy 82 (Leland/Greenwood exit) go east to Indianola---easy drive and you will be in the Delta all the way.
Have a safe and fun trip.
The shack up inn, a wonderful place, but out of town.
The Juke Joint Festival weekend coming up -http://www.jukejointfestival.com/
Some amazing places nearby - http://msbluestrail.org/ -A great resource type in a name and it will provide a map.
Our motto every time we got behind the wheel and at intersections was "keep to the RIGHT"
Check the road trip forums as well.
Hi old_brewster , how did your trip go? we're planning a similar trip next Easter.
Make sure to visit Red's, Ground Zero, Bluesberry, and CatHead.
The trip was good, but I finished sharing travel with fellow musicians. We were going to Clarkesdale for a music camp. Coming from New Zealand it was great to be a passenger and just looking. I am planning to go back again 2016.
We also had a great time, we're looking to go back in 2016 for the Juke Joint Festival, the weekend of 16 April.