I lucked into finding the best hotel in Clarksdale, MS. The place is named the Lofts at the Five & Dime. Located in the heart of downtown, this hotel has only five loft suites. Each suite has a den/kitchen combo and large sleeping room. The den and kitchen is designed for entertaining and has a huge island bar, flat screen TV, and luxurious chairs and couch. My suite was the nicest hotel suite that I have ever stayed in.....Really!!! Try it, you will love it!