With its ideal location on the magnificently rugged Oregon Coast, the entire city of Newport is a natural observatory that offers a number of fun and educational activities for the whole family. Spend the morning exploring tide pools, combing the beach for fossils and spotting marine life in their natural habitats. Then head over to the Oregon Coast Aquarium where you can pet an octopus and walk through a glass tunnel surrounded by sharks. Newport is also home to two lighthouses, one of which is the tallest on the Oregon Coast. Historic Nye Beach, with its colorful cottages and laid-back atmosphere, is the perfect spot for a picnic and a quick rest from all the sightseeing.

Eugene is a great city for the arts and outdoors. You can shop from a variety of local artisans, get lost in a museum or dive into the thriving culinary scene. Visit craft breweries and artisan wineries while winning prizes with the Eugene Ale Trail and Pinot Bingo programs. Known as Track Town USA, Eugene is home to track and field year-round; in the fall, it’s a college football hub. There are scenic bike rides and urban hikes to fit visitors of all abilities in all seasons.

Named from the anglicized form of the Hebrew word "shalom," meaning peace, Salem provides visitors with exactly that - plus a horde of historic sites to explore and plenty of opportunities for outdoor recreation. Oregon's capital, one of the oldest cities in the state, exudes simple, small-town hospitality with just enough politics and culture to keep things interesting. Tour the grand, gold-domed State Capitol to learn about the workings of the government, then head to the observation deck for a fantastic view of Salem and its surrounding area. Although the whole city is a living history lesson, brimming with old buildings and landmarks, the Mill Mission Museum is a definite standout. Art buffs should not miss the impressive Pacific Northwest collection at the Hallie Ford Art Museum. In between sights, take time to people watch or picnic at Bush's Pasture Park, or enjoy wine tasting at some of the local vineyards. Salem's idyllic setting, in the heart of the emerald Willamette Valley, coupled with its historic role as political hub for Oregon make it the perfect choice for a delightful and interesting weekend away.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."