Knysna stands out on South Africa's famed Garden Route thanks to the sandstone cliffs that dramatically separate its tranquil lagoon from the pounding surf of the Indian Ocean. It's also home to the country's largest indigenous forest. Hop aboard a ferry for a ride through the scenic highlights. The Millwood Mines at Jubilee Creek, site of a major gold rush in 1885, provide a picturesque spot for a picnic. Be sure to try some local oysters during the renowned annual festival.

The caves of Plettenberg Bay are wrinkles in time, lined with ancient artifacts that date to the Middle Stone Age. Under the sun, Robberg, Central and Lookout beaches are pristine stretches of white sand, magnets for tourists, seagulls and dolphins, who bob playfully just off shore. Wildlife lovers will delight at the Birds of Eden aviary and Monkeyland. (How can you not have fun in a place called Monkeyland?)

South Africa’s most popular tourist destination offers the urban thrills of Cape Town, its adjacent wine country and an aura of the rich political history of South Africa. The Overberg's perfect whale-watching perches provide excitement of a different nature. The Garden Route's lakes and forests and the Klein Karoo's ostrich-farming towns and vineyards present another take on the Cape. For extra kicks, try bungee jumping or cage-diving among Great Whites.

The village of Franschhoek (French Corner), tucked into the Cape Winelands of South Africa, is known as the country's food and wine capital. Galleries and antique shops fill the tree-lined streets, and vineyards established more than 300 years ago cascade over the hills just outside town. Local activities range from wine-tasting tours to trout fishing and hiking. The Huguenot Memorial Museum honors the town's early settlers, who fled religious persecution in France.

Hiking trails and art galleries abound in Stellenbosch, but it's wine that takes center stage. More than 100 wine cellars, most open to the public, surround the oak-lined South African town, and tasting tours operate daily. Winter brings a four-day festival celebrating the local vintages. The historic town center houses the trading-post style shop Oom Samie se Winkel, the Neo-Gothic Moederkerk church, and museums dedicated to toys, military memorabilia, autos and early life on the Cape.

Pretoria is a vision of purple, thanks to its plethora of blossoming trees that gave the South African metropolis its nickname: Jacaranda City. Give in to the animal magnetism of the National Zoological Gardens of South Africa, then get up close and personal with the big, bad kitties of the Cheetah Research and Breeding Centre. The buildings of Pretoria reflect diverse architectural styles and influences, creating a unique urban landscape.

The largest game reserve in South Africa, Kruger National Park is basically a synonym for the word "safari." Home to over 500 bird species, 100 reptiles, nearly 150 mammals, multiple archaeological sites, and a stunningly diversity of trees and flowers, Kruger is the country’s flagship national park. Adventurers can explore the park in a 4x4, take a bush walk or fly above in a hot-air balloon.

The Zanzibar Archipelago, located in the Indian Ocean 15 miles off the coast of Tanzania, is a breathtaking spot to escape from the world. You’ll enjoy clear, turquoise-blue water; shallow sandbars perfect for wading; and many small, nearly deserted islands virtually unvisited by tourists. Explore the World Heritage Site of Stone Town, Zanzibar City’s old quarter. Or just go beach to beach between tiny fishing villages—each one's better than the next.

Mauritius is arguably Africa’s wealthiest destination, a tropical paradise with tons to do. Port Louis, the modern capital of this 38-mile by 29-mile island, is a bustling port with a revitalized waterfront and a busy market. But most visitors gravitate toward resort areas such as Mont Choisy, quiet Trou-aux-Biches and the more bustling Flic en Flac, popular with scuba divers. Rivière Noire is ideal for those looking for great deep-sea fishing.