In St. John's, the capital city of Antigua, farmers markets, candy- colored architecture and the ruins of sugar plantations vie for attention with a kaleidoscope of coral reefs and sailing adventures. Salute the white baroque towers of St. John's Cathedral that dominate the skyline before joining the flocks of cruise passengers on a Heritage Quay shopping excursion. To experience the island's early cultures, visit the Museum of Antigua and Barbuda, housed in a 1750s colonial courthouse.

Giant anteaters, howler monkeys, ocelots, endangered jaguars and clouds of butterflies are among the attractions at this World Heritage-designated park that marks the border between Brazil and Argentina. By foot or by raft, explorers can view one of the world's most stunning waterfalls, Iguazu Falls. Among the park's 270 waterfalls, spectacular Devil's Throat combines 14 falls and generates a "perpetual rainbow" in good weather.

The Cape Verdean island of Sal is all about the beach, baby. White sand stretches along glassy turquoise waters—perfect for a lazy day of sunning or some heart-pumping watersports. Snorkelers and divers will find plenty of tropical fish, turtles, and dolphins to look at. On dry land, kids (and grownups!) will marvel at the Terra Boa mirage, an optical illusion that conjures a peaceful-looking lake in the middle of a large, flat plain.

Set in the heart of the Algarve, the tiny fishing town of Olhos de Agua surrounds a sandy cove lapped by the Atlantic Ocean. Despite its proximity to the developed Albufeira resort, Olhos de Agua retains its authentic Mediterranean charm.