The village of Franschhoek (French Corner), tucked into the Cape Winelands of South Africa, is known as the country's food and wine capital. Galleries and antique shops fill the tree-lined streets, and vineyards established more than 300 years ago cascade over the hills just outside town. Local activities range from wine-tasting tours to trout fishing and hiking. The Huguenot Memorial Museum honors the town's early settlers, who fled religious persecution in France.

From flat-topped Table Mountain down to the blue waters of Table Bay, Cape Town is simply stunning, but the city doesn't thrive by its looks alone. Proudly multicultural, its flourishing arts, dining, and nightlife scenes are proof of this modern metropolis' creativity and innovative spirit.

Beautiful Hermanus is a South African seaside town that’s a popular whale-watching site. An initial visit to the Old Harbour Museum will acquaint you with the area’s rich fishing history and impress you with a massive exhibit of a whale skeleton. With dozens of area vineyards, Hermanus is a great base for a guided wine tasting tour.

South Africa’s most popular tourist destination offers the urban thrills of Cape Town, its adjacent wine country and an aura of the rich political history of South Africa. The Overberg's perfect whale-watching perches provide excitement of a different nature. The Garden Route's lakes and forests and the Klein Karoo's ostrich-farming towns and vineyards present another take on the Cape. For extra kicks, try bungee jumping or cage-diving among Great Whites.

Roughly translated as "fountain of flowers," Bloemfontein is known as the City of Roses, both because of the abundance of the blooms throughout the city and the annual festival dedicated to the flower. As the seat of the South African Supreme Court, the city is the judicial capital of the country as well as the provincial capital of Free State. Several sports teams and stadiums also call the city home, and its many museums outline the history of the region.

The Indian and colonial influences in this South African beach city can’t be missed, and the blend of cultures and architecture makes Durban unique in South Africa. Durban’s Golden Mile is a destination for surfers, families and fisherman, due to its blend of natural beauty and modern resort. Major-city attractions abound, making this a good destination for families and couples alike.

Miles of powder-white beaches hug the coast at Belle Mare, where championship golf courses, posh resorts, a family-friendly water park and abundant aquatic sports ensure activity-filled days. Deep-sea fishing for tuna, marlin and mako shark is especially popular in this eastern Mauritius enclave. Belle Mare also serves as a convenient base camp for a trek to 1,575-foot Lion Mountain, where sweeping views reward those who make the challenging hike to its peak.

Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)

Founded in 1565 by the Order of St John as a refuge for soldiers returning from the Crusades, Valletta is now the capital of Malta and a piece of living history. With an unsurpassed collection of original Baroque architecture, fortified city walls overlooking the Mediterranean Sea, and the spectacular Co-Cathedral of St John, which features intricately carved stone vaults and a famed painting by Caravaggio, it is no wonder that this smallest of European capital cities is a world heritage site.

The beaches that stretch along Kudasi's Aegean coastline are as diverse in terrain as they are in ambiance. Ladies’ Beach, thusly named because it was once a for women only, is packed with nightclubs, souvenir vendors, restaurants and, of course, sunbathers and swimmers. Grass-lined Gold Beach is well-manicured and peaceful. Ride a horse from there to Long Beach, a playground of beach bars, pool tables and water sports.