Charming Mackinac Island is a throwback to old-timey seaside leisure, from the candy-colored facades of downtown shops to the impressive (record-breaking, in fact) front porch of the Victorian-era Grand Hotel. Mackinac is world-famous for its homemade fudge, available in every flavor you can imagine. Work off your sugar high with a round of golf, a bike ride along a seaside trail, or exploring the limestone bluffs of Mackinac Island State Park.

Discover an essential chapter of America's history in the cobblestone streets, river walks and monuments of Richmond. Originally a colonial settlement, Virginia's capital is now a thriving hub for culture, shopping and outdoor fun. Explore Civil War history at the American Civil War Museum, stroll along the canal downtown or test your nerve whitewater rafting on the James River. With lively neighbourhoods and a vibrant restaurant scene, Richmond is perfect for a quick break or an extended getaway.

A city with a 200-year Southern heritage, visitors will find activities that celebrate Huntsville’s rich history, as well as attractions that highlight the city’s scientific side. At the Alabama Constitution Village, villagers in period clothing take time from their daily chores to guide you through eight reconstructed Federal style buildings. Younger visitors will love the 150 hands-on activities at the Sci-Quest Hands-on Science Centre and older children will learn what it takes to be an astronaut at the U.S. Space and Rocket Centre. Looking for outings with a cultural flair? Landmarks such as the Huntsville Botanical Garden and Huntsville Museum of Art are must sees.

Vines, wines and the people who love them are central to the economy of Napa Valley. Other treats for the taste buds are in store, too, in the form of local olive oils, tomatoes, cheeses and mustard. The other senses are catered for with a vibrant visual arts scene. Hire a car or book a taxi or limousine to travel safely between sights. The Napa Valley Wine Train offers an unusual way to experience the views and vintages. A relaxing array of spas and mud baths and the Old Faithful geyser are attractions in Calistoga.

Amsterdam is truly a biker’s city, although pedaling along the labyrinthine streets can get a little chaotic. Stick to walking and you won’t be disappointed. The gentle canals make a perfect backdrop for exploring the Jordaan and Rembrandtplein square. Pop into the Red Light District if you must—if only so you can say you’ve been there. The Anne Frank House is one of the most moving experiences a traveller can have, and the Van Gogh Museum boasts a sensational collection of works.

We hear the question, "What’s the next Prague?" a lot. But while we’re all for discovering great new destinations, we hardly think Prague is over. Sure, everyone’s heard of it, but it’s still a grand city with extraordinary historic and cultural sights, and it’s definitely worth a visit. The often-rebuilt Prague Castle has overlooked the city since the 9th century, and the synagogues and cemetery of the Jewish Quarter are must-sees. Nightlife here is diverse and plentiful, from trendy clubs to sophisticated wine bars to late-night cellar bars.