Knysna stands out on South Africa's famed Garden Route thanks to the sandstone cliffs that dramatically separate its tranquil lagoon from the pounding surf of the Indian Ocean. It's also home to the country's largest indigenous forest. Hop aboard a ferry for a ride through the scenic highlights. The Millwood Mines at Jubilee Creek, site of a major gold rush in 1885, provide a picturesque spot for a picnic. Be sure to try some local oysters during the renowned annual festival.

South Africa’s most popular tourist destination offers the urban thrills of Cape Town, its adjacent wine country and an aura of the rich political history of South Africa. The Overberg's perfect whale-watching perches provide excitement of a different nature. The Garden Route's lakes and forests and the Klein Karoo's ostrich-farming towns and vineyards present another take on the Cape. For extra kicks, try bungee jumping or cage-diving among Great Whites.

The Indian and colonial influences in this South African beach city can’t be missed, and the blend of cultures and architecture makes Durban unique in South Africa. Durban’s Golden Mile is a destination for surfers, families and fisherman, due to its blend of natural beauty and modern resort. Major-city attractions abound, making this a good destination for families and couples alike.

Miles of powder-white beaches hug the coast at Belle Mare, where championship golf courses, posh resorts, a family-friendly water park and abundant aquatic sports ensure activity-filled days. Deep-sea fishing for tuna, marlin and mako shark is especially popular in this eastern Mauritius enclave. Belle Mare also serves as a convenient base camp for a trek to 1,575-foot Lion Mountain, where sweeping views reward those who make the challenging hike to its peak.

The island capital of the Maldives teems with high rises and narrow streets, all ringed by seawalls. Shopaholics can savor Male's flavors in the local markets, which are packed with fresh produce, and along Chaandanee Magu, the spot for local souvenirs, such as carved wooden dhonis, miniature replicas of the boats dotting area waters. The golden-domed Friday Mosque presides over the landscape, while the underwater riches of the atolls lure scuba enthusiasts from around the globe.

Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)

The Greek island of Santorini is a blissful spot for a getaway, and its capital, Fira, is a vision of dramatic cliffs and pristine whitewashed buildings. The Archaeological Museum contains Minoan artifacts from Fira’s ancient foundations, while several churches and monasteries offer a glimpse into the historical and contemporary religious make up of this beautiful village. Exploring the shops and cafes along Fira’s narrow footpaths is a leisurely way to spend an afternoon.

Once one of ancient Greece’s most important cities, today Syracuse (Siracusa in Italian) is a lively town of about 125,000 on Sicily’s southeast coast. The city overflows with amazing remnants from its long history. Romans, Vandals and Normans are but a few of those who ruled here after the Greeks. In Syracuse’s harbor, Ortygia Island (also called Città Vecchia or Old City) is the site of many of the main attractions, including the seventh-century cathedral and the Fountain of Arethusa.