Part of the Maltese archipelago, Gozo is the second-largest of the seven-island chain and basks in the Mediterranean off the coast of Sicily. More rural than its sister island, Malta, Gozo has a population of 31,000. Home to some of the oldest religious structures in the world, the fascinating Ggantija temples, the island offers dramatic orange-red sands and perfect snorkeling waters at striking Ramla Bay. Rickety buses ply Gozo's roads, making getting about the island an exciting component of your trip.

One of Islam’s most holy cities, Medina, is a sprawl of minarets and shops wrapped around the landmark, the Prophet’s Mosque. Like the rest of central Medina, it’s for Muslims only and is surrounded by plenty of hotels and eateries to welcome the pilgrimage crowd.