Perhaps best known these days as the setting for the book and movie “Under the Tuscan Sun,” gorgeous hillside Cortona has a long history dating back even before its time as an important Etruscan center. Top attractions include the Duomo (Cathedral), the small Museo Diocesano across the piazza with its superb art collection, and the fascinating Museo dell'Accademia Etrusca with its assembly of Etruscan and Roman era items. Cortona is also bursting with splendid churches spanning many periods.

Best known as the birthplace of St. Francis, Italy's patron saint, Assisi lies amid Umbria's rolling hills. Religious pilgrims have come here for centuries to visit the Basilica of San Francesco (where St. Francis is buried) and the Basilica of Santa Chiara (to see the tomb of St. Clare). Visit the Eremo delle Carceri to see caves where mediaeval hermits withdrew from the world. (You may find such solitude quite appealing—especially if you're here on a daytrip from Rome!)

Riccione is sun-soaked and stylish, an ancient Italian settlement with modern, global flair. Located in the heart of the Eastern Riviera, this coastal destination is the perfect place to sip a cocktail while lounging on golden sands. At night, party people spill from the open-air discos onto the beach, creating a surreal sort of everlasting outdoor party. Zip down a slide at a water park, spin it up on a guided cycling tour, or visit the nearby Misano World Circuit racetrack for an unforgettable getaway.

Located near Ravenna, Milano Marittima is a highlight among the tranquil resort towns that line this stretch of the Adriatic Sea. Beyond its beaches, the town’s lush nature park and Casa delle Farfalle (Butterfly House) are some of its star attractions.

One of Italy’s most visited regions, Veneto in the country’s northeast was independent for centuries until 1797, when Napoleon invaded. It then bounced among French, Austrian and Italian domination. Bordered by some of Europe’s most beautiful elements (the Adriatic Sea to its east, Lake Garda to its west, the Dolomites to its north, and the Po River to its south), Veneto is known for agriculturally rich valleys flowing down from Alps and for important cities like Venice, Verona and Padua.

Corfu is studded with whitewashed houses, Byzantine churches, and the remains of Venetian fortresses and Greek temples. Wander the ancient streets of the Roman village of Kassiopi or explore the central Esplanade of the eponymous Corfu Town. For a DIY spa experience, lather yourself in mineral mud on the shore of the Canal D’Amour. Legend has it that the waterfalls of Nymphes used to attract the mythological beauties of the same name, who would flock to the village to bathe in the pristine waters.

One of Poland’s most beautiful cities, Gdansk, on the Baltic Sea, has played major roles in history, especially in the 20th-century. It was the 1939 flash point of World War II, and then in 1980, the birthplace of the Solidarnosc labor movement, ushering the end of Communist domination in Eastern Europe. Gdansk’s Old Town, painstakingly reconstructed to its Hanseatic League glory after being leveled in World War II, is a highlight. The 14th-century Town Hall houses the city’s historical museum.

Pretoria is a vision of purple, thanks to its plethora of blossoming trees that gave the South African metropolis its nickname: Jacaranda City. Give in to the animal magnetism of the National Zoological Gardens of South Africa, then get up close and personal with the big, bad kitties of the Cheetah Research and Breeding Centre. The buildings of Pretoria reflect diverse architectural styles and influences, creating a unique urban landscape.